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Cancer Risk Among Firefighters: A Review and Meta-Analysis of 32 Studies

By MagneGrip, Jun 7 2016 12:01PM

Journal of Occupational and Environmental Medicine:

November 2006 – Volume 48 – Issue 11 – pp 1189-1202

doi: 10.1097/01.jom.0000246229.68697.90

Original Articles

LeMasters, Grace K. PhD; Genaidy, Ash M. PhD; Succop, Paul PhD; Deddens, James PhD; Sobeih, Tarek MD, PhD; Barriera-Viruet, Heriberto PhD; Dunning, Kari PhD; Lockey, James MD, MS


Objective: The objective of this study was to review 32 studies on firefighters and to quantitatively and qualitatively determine the cancer risk using a meta-analysis.

Methods: A comprehensive search of computerized databases and bibliographies from identified articles was performed. Three criteria used to assess the probable, possible, or unlikely risk for 21 cancers included pattern of meta-relative risks, study type, and heterogeneity testing.

Results: The findings indicated that firefighters had a probable cancer risk for multiple myeloma with a summary risk estimate (SRE) of 1.53 and 95% confidence interval (CI) of 1.21-1.94, non-Hodgkin lymphoma (SRE = 1.51, 95% CI = 1.31-1.73) and prostate (SRE = 1.28; 95% CI = 1.15-1.43). Testicular cancer was upgraded to probable because it had the highest summary risk estimate (SRE = 2.02; 95% CI = 1.30-3.13). Eight additional cancers were listed as having a possible association with firefighting.

Conclusions: Our results confirm previous findings of an elevated metarelative risk for multiple myeloma among firefighters. In addition, a probable association with non-Hodgkin lymphoma, prostate, and testicular cancer was demonstrated.

©2006The American College of Occupational and Environmental Medicine

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